Early cranial ultrasound lesions predict microcephaly at age 2 years in preterm infants

Kalpathy S Krishnamoorthy, Karl C K Kuban, T Michael O’Shea, Sjirk J Westra, Elizabeth N Allred, Alan Leviton, ELGAN Study Co-investigators

J Child Neurol. 2011;26:188-94

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OR (95% CI) for MC associated with different HUS images were IVH, 1.5 (0.8-3.0); VM, 3.3 (1.8-6.0); an ED, 1.6 (0.7-3.5); and EL, 3.1 (1.5-6.2). VM and EL had similar low PPV (24% and 27%, respectively) and high NPV (91% and 90%, respectively) for MC. VM had higher sensitivity for MC than did EL (24% vs 16%, respectively). Focal WM lesion (EL) and diffuse WMD (VM) predict increased risk of MC.