Early postnatal illness severity scores predict neurodevelopmental impairments at 10 years of age in children born extremely preterm

J W Logan, O Dammann, E N Allred, C Dammann, K Beam, R M Joseph, T M O’Shea, A Leviton, K C K Kuban

J Perinatol. 2017 May;37:606-614

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OBJECTIVE: We sought to evaluate to what extent SNAP-II is predictive of cognitive and other neurodevelopmental impairments at 10 years of age.

RESULTS: An undesirably high SNAP-II (⩾30), present in 23% of participants, was associated with an increased risk of cognitive impairment (IQ, executive function, language ability), adverse neurological outcomes (epilepsy, impaired gross motor function), behavioral abnormalities (attention deficit disorder and hyperactivity), social dysfunction (autistic spectrum disorder) and education-related adversities (school achievement and need for educational supports.

CONCLUSION: Among very preterm newborns, physiologic derangements present in the first 12 postnatal hours are associated with dysfunctions in several neurodevelopmental domains at 10 years of age.