Microbiologic and histologic characteristics of the extremely preterm infant’s placenta predict white matter damage and later cerebral palsy. the ELGAN study

Alan Leviton, Elizabeth N Allred, Karl C K Kuban, Jonathan L Hecht, Andrew B Onderdonk, T Michael O’shea, Nigel Paneth

Pediatr Res. 2010;67:95-101

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Recovery of single microorganism predicts EL, whereas polymicrobial cultures & skin flora predicted VM and EL. DP CP predicted by single or multiple organisms, and skin flora. Histologic inflammation predicted VM and DP CP. Risk of VM, but not DP CP, associated with organism recovery, heightened by presence of histologic inflammation. Organism recovery not needed for placenta inflammation to predict DP CP