Microorganisms in the Placenta: Links to Early-Life Inflammation and Neurodevelopment in Children

Martha Scott Tomlinson, Kun Lu, Jill R Stewart, Carmen J Marsit, T Michael O’Shea, Rebecca C Fry

Clin Microbiol Rev. 2019;32(3). pii: e00103-18.

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Prenatal exposure to stressors can influence childhood health. Microbial infection of intrauterine environment, esp in placenta, is associated with deleterious outcomes. Microbia are associated with epigenetic placental changes. We review research of microbes in placenta and its associations among microbes, placental DNA methylation, perinatal inflammation, and neurodevelopmental outcomes.