Socioeconomic status and early 1 blood concentrations of inflammation-related and neurotrophic proteins among extremely preterm newborns

Alan Leviton, Elizabeth N Allred, Olaf Dammann, Robert M Joseph, Raina N Fichorova, T Michael O’Shea, Karl C K Kuban

PLOS ONE 201926;14(3):e0214154

PubMed Link

The main objective of this study was to evaluate the relationship between mother’s socioeconomic disadvantage and blood concentrations of inflammation-related proteins among EP newborns. We used 3 indicators/correlates of socioeconomic disadvantage, mother’s eligibility for government-provided medical care insurance (Medicaid), mother’s formal education level, and mother’s IQ. Indicators of socioeconomic disadvantage are associated with modestly increased risk of systemic inflammation in postnatal blood during the first postnatal month and with a slightly reduced risk of a neurotrophic signal, but do not confound relationships between inflammatory proteins and outcomes.