Antecedents and early correlates of high and low concentrations of angiogenic proteins in extremely preterm newborns

Alan Leviton, Stanthia Ryan, Elizabeth N Allred, Raina N Fichorova, T Michael O’Shea, Karl Kuban, Olaf Dammann, ELGAN Study Investigators

Clin Chim Acta. 2017 Aug;471:1-5

PubMed Link

BACKGROUND: To identify antecedents & very early correlates of low concentrations of angiogenic proteins in blood of extremely preterm newborns in first postnatal month. RESULTS: Delivery for medical indications or severely IUGR were more likely to have low day-1 blood concentrations of VEGF, VEGF-R2, Ang-1, and PIGF. Systemic inflammation accompanied top quartile concentrations of all 6 angiogenic proteins. CONCLUSIONS: Low day-1 values of angiogenic proteins associated w/placenta insufficiency/dysfunction. High concentrations associated w/inflammation in first month.