H Reeve Bright, Kikelomo Babata, Elizabeth N Allred, Carmina Erdei, Karl C K Kuban, Robert M Joseph, T Michael O’Shea, Alan Leviton, Olaf Dammann, ELGAN Study Investigators
J Pediatr. 2017 Aug;187:43-49.
OBJECTIVE: To evaluate difference in 10-year neurocognitive outcomes between E:LGANS with/without suspected or confirmed bacteremia .
STUDY DESIGN: Definite (culture-positive) late-onset bacteremia in postnatal weeks 2-4 was identified in 223 children, and 129 children had suspected bacteremia.
RESULTS / CONCLUSIONS: Infants with lowest GA and B Wt z-score had highest prevalence of definite and suspected late-onset bacteremia. Definite bacteremia associated with worse performance w/IQ, language, academic achievement, and EF. Adjustment for low IQ attenuated associations between bacteremia and dysfunctions at 10 years. Children with suspected bacteremia did not differ from no bacteremia.