Neurocognitive Outcomes at 10 Years of Age in Extremely Preterm Newborns with Late-Onset Bacteremia

H Reeve Bright, Kikelomo Babata, Elizabeth N Allred, Carmina Erdei, Karl C K Kuban, Robert M Joseph, T Michael O’Shea, Alan Leviton, Olaf Dammann, ELGAN Study Investigators

J Pediatr. 2017 Aug;187:43-49.

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OBJECTIVE: To evaluate difference in 10-year neurocognitive outcomes between E:LGANS with/without suspected or confirmed bacteremia .

STUDY DESIGN: Definite (culture-positive) late-onset bacteremia in postnatal weeks 2-4 was identified in 223 children, and 129 children had suspected bacteremia.

RESULTS / CONCLUSIONS: Infants with lowest GA and B Wt z-score had highest prevalence of definite and suspected late-onset bacteremia. Definite bacteremia associated with worse performance w/IQ, language, academic achievement, and EF. Adjustment for low IQ attenuated associations between bacteremia and dysfunctions at 10 years. Children with suspected bacteremia did not differ from no bacteremia.