Antecedents of inflammation biomarkers in preterm newborns on days 21 and 28

Alan Leviton, Elizabeth N Allred, Raina N Fichorova, Karl C K Kuban, T Michael O’Shea, Olaf Dammann, ELGAN Study Investigators

Acta Paediatr. 2016 Mar;105(3):274-80.

PubMed Link

The purpose of this study was to identify antecedents of systemic inflammation evident during postnatal weeks three and four. We measured protein in blood spots collected on postnatal days 21 (N = 176) and 28 (N = 157) from ELGANs and found that infants born for maternal and fetal indications were more likely than peers to have top quartile concentrations of IL-beta, IL-8, TNF-alpha, and ICAM-1 on days 21 and 28. Similarly, infants whose B. Wt. Z-score was < -2 or between -1 and -2 were also more likely  to have elevated concentrations of these proteins.