Antecedents of perinatal cerebral WMD with & without IVH in very preterm newborns

J Wells Logan, Sjirk J Westra, Elizabeth N Allred, T Michael O’Shea, Karl Kuban, Nigel Paneth, Alan Leviton, ELGAN Study investigators

Pediatr Neurol. 2013;49:88-96.

PubMed Link

Risk of hypoechoic (HE) lesion with IVH (N = 61) associated with gestation <25 weeks, high SNAP, early recurrent or prolonged acidemia, analgesic exposure, & mech vent at 1 week. Risk of a HE lesion w/o IVH differs from HE lesion with IVH (~PVHI). Suggests HE lesions w/ IVH may have different causal pathway than HE lesions w/o IVH, (~PVL(