Antenatal antecedents of cognitive impairment at 24 months in extremely low gestational age newborns

Jennifer B Helderman, Thomas M O’Shea, Karl C K Kuban, Elizabeth N Allred, Jonathan L Hecht, Olaf Dammann, Nigel Paneth, T F McElrath, Andrew Onderdonk, Alan Leviton, ELGAN study Investigators

Pediatrics. 2012;129:494-502

PubMed Link

103 infants (11%) had MDI <55, and 99 (11%) an MDI between 55-69. No associations between placental orgs & dev delay. Factors strongly associated with MDI <55: fetal vessel thrombosis (OR 3.1; 95% CI 1.2, 7.7), maternal BMI >30 (OR 2.0; 95% CI 1.1, 3.5), mat ed ≤12 years (OR 3.4; 95% CI 1.9, 6.2), nonwhite (OR 2.2; 95% CI 1.3, 3.8), birth wt z score < -2 (OR 2.8; 95% CI 1.1, 6.9), male (OR 2.7; 95% CI 1.6, 4.5).

ELGAN