Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery

Sunita Trivedi, Maria Joachim, Thomas McElrath, Harvey J Kliman, Elizabeth N Allred, Raina N Fichorova, Andrew Onderdonk, Fernanda Heitor, Leila Chaychi, Alan Leviton, Joseph A Majzoub, Extremely Low Gestational Age Newborns (ELGAN) study investigators

Am J Obstet Gynecol. 2012;206:236.e1-8

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Among ELGANs, spontaneous (vs induced) delivery was associated with less placental CRH expression and more frequent placental inflammation and infection.

Inflammation and infection, rather than premature activation of the fetal adrenal axis, should be the major focus of research to prevent extremely preterm human birth.