Antenatal Complications and the Risk of Neonatal Cerebral White Matter Damage and Later Cerebral Palsy in Children Born at an Extremely Low GA

Thomas F McElrath, Elizabeth N Allred, Kim A Boggess, Karl Kuban, T Michael O’Shea, Nigel Paneth, Alan Leviton, ELGAN Study Investigators

Am J Epidemiol 2009;170:819-828.

PubMed Link

Infants w/ACS had lower risks of VMeg & EL (10% vs. 23%, P < 0.001 & 7% vs. 11%, P = 0.06). Risk of VMeg ↑ w/preterm labor: OR = 2.3, 95% CI: 1.1, 4.9), PROM (OR = 3.6, 95% CI: 1.5, 8.7), and cervical insuff (OR = 2.8, 95% CI: 1.4, 5.5) compared w/ infants delivered for PE. Risk of EL lesion was ↑ w/ preterm labor (OR = 2.7, 95% CI: 1.2, 5.7) and IUGR (OR = 3.3, 95% CI: 1.2, 9.4). Doubling of DP risk w/preterm labor & PROM not sign, nor was doubling of QP and tripling of DP risk ass’ed w/ cervical insuff

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