Blood gases and retinopathy of prematurity: the ELGAN Study

Alisse K Hauspurg, Elizabeth N Allred, Deborah K Vanderveen, Minghua Chen, Francis J Bednarek, Cynthia Cole, Richard A Ehrenkranz, Alan Leviton, Olaf Dammann

Neonatology. 2011;99:104-11

PubMed Link

MVA indicate exposure to PCO(2) in highest quartile predicts ROP (stage 3- 5: OR = 1.6, – 1.1-2.3); zone 1: 2.0, 1.1-3.6; prethreshold/threshold: 1.9, 1.2-3.0; plus disease: 1.8, 1.1-2.9). Estimates similar for a low pH for zone 1 (2.1, 1.2-3.8), and prethreshold-threshold (1.8, 1.1-2.8). A PaO(2) in highest quartile for GA on at least 2 postnatal days associated with doubled risk of ROP, and 70% risk ↑ for plus disease.

ELGAN