Antecedents of chronic lung disease following three patterns of early respiratory disease in preterm infants

Matthew Laughon, Carl Bose, Elizabeth N Allred, T Michael O’Shea, Richard A Ehrenkranz, Linda J Van Marter, Alan Leviton, ELGAN Study Investigators

Arch Dis Child Fetal Neonatal Ed. 2011;96:F114-20

PubMed Link

CLD 69% of infants with EPPD, 52% with PD, and 17% in the Low FiO(2) group. Birth weight z score <-1 conveyed information about CLD risk in all three groups and was the major risk factor for infants in the Low FiO(2) group (OR 27; 95% CI 7 to 95). MV at 7 days associated with ↑ risk in PD (OR 4.2, 95% CI 2.5 to 6.9) and EPPD groups (OR 2.7, 95% CI 1.5 to 4.7), but not Low FiO(2) group. Among infants with little exposure to oxygen, fetal growth restriction, not MV, is factor with strongest association with CLD