Circulating biomarkers in extremely preterm infants associated with ultrasound indicators of brain damage

Alan Leviton, Elizabeth N Allred, Raina N Fichorova, T Michael O’Shea, Lynn A Fordham, Karl K C Kuban, Olaf Dammann

Eur J Paediatr Neurol. 2018 Jan 31. pii: S1090-3798(17)30146-0.

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Study participants were 1219 children who had a cranial U/S in NICU and blood specimens during first month. High concentrations of multiple inflammation-related proteins during first 2 weeks associated with increased risk of VM , while high concentrations of just 3 inflammation-related proteins associated with risk of an EL (IL-6, IL-8, ICAM-1), especially on day 7. Concomitant high IL6R and bFGF appeared to modulate the increased risks of VM and EL associated with inflammation.