Comparison of frozen and unfrozen blood spots for gene expression studies

Changshuai Wei, Qing Lu, Sok Kean Khoo, Madeleine Lenski, Raina N Fichorova, Alan Leviton, Nigel Paneth

J Pediatr 2014;164:189-191.E1.

PubMed Link

We studied gene expression in 9 pairs newborn blood spots stored 8-10 yrs in frozen or unfrozen state. Fewer genes expressed in unfrozen spots, but avg correlation coeff for gene expression for frozen & unfrozen state was 0.771 (95% CI, 0.700-0.828).

ELGAN