Cranial ultrasound lesions in the NICU predict cerebral palsy at age 2 years in children who were born at extremely low gestational age

Karl C K Kuban, Elizabeth N Allred, T Michael O’Shea, Nigel Paneth, Marcello Pagano, Olaf Dammann, Alan Leviton, Adré Du Plessis, Sjirk J Westra, Cindy R Miller, Haim Bassan, Kalpathy Krishnamoorthy, Joseph Junewick, Nicholas Olomu, Elaine Romano, Joanna Seibert, Steve Engelke, Padmani Karna, Daniel Batton, Sunila E O’Connor, Cecelia E Keller, ELGAN study investigators

J Child Neurol 2009;24:63-72

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HUS in 1053 infants were read with respect to IVH, VMeg, and EL. Standardized neuro exams classified CP, and functional impairment. 44% w/ VMeg and 52% w/ EL developed cerebral palsy. Compared with no ultrasound abnormalities, children with were 24 X > likely to have QP and 29 X > likely to have HP. Children w/VMeg were 17 X > likely to have QP or HP. 43 % w/CP had nl HUS. EL, late VMeg had ↑probability of CP, esp QP. Nearly ½ w/CP had no HUS abnormality.