Duration of Systemic Inflammation in the First Postnatal Month Among Infants Born Before the 28th Week of Gestation

Olaf Dammann, Elizabeth N Allred, Raina N Fichorova, Karl Kuban, T Michael O’Shea, Alan Leviton, ELGAN Study Investigators

Inflammation. 2016 Apr;39(2):672-7. doi: 10.1007/s10753-015-0293-z.

PubMed Link

ELGANs that exhibit fetal and neonatal systemic inflammatory responses are at increased risk for developmental adversity, especially if the inflammatory process is sustained. We evaluated PICK patterns in 1220 ELGANs on one or more of postnatal days 1, 7, 14, 21, and 28. ELGANs who have elevated systemic levels of IL-6R, TNF- α, or RANTES on their first postnatal day are twice as likely to have elevated levels of these cytokines at the end of each of the first postnatal month. In some extremely preterm newborns, inflammatory processes can be sustained over weeks.