The Development of Extremely Preterm Infants Born to Women Who Had Genitourinary Infections During Pregnancy

Alan Leviton, Elizabeth N Allred, Karl C K Kuban, T Michael O’Shea, Nigel Paneth, Andrew B Onderdonk, Raina N Fichorova, Olaf Dammann, ELGAN Study Investigators

Am J Epidemiol. 2016 Jan 1;183(1):28-35

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The mothers of 989 ELGAN infants who reported a UTI were less likely than others to have a very low MDI (adjusted odds ratio = 0.5; 95% confidence interval: 0.3, 0.8), whereas infants born to women who reported a CVI were more likely than others to have a low PDI (adjusted odds ratio = 1.7; 95% confidence interval: 1.04, 2.7). In this high-risk sample, maternal gestational CVI, but not UTI, was associated with a higher risk of impaired motor development at 2 yrs of age. The apparent protective effect of UTI might be spurious, reflect confounding due to untreated asymptomatic bacteriuria among women who were not given a diagnosis of UTI, or reflect preconditioning.