Early Postnatal IGF-1 and IGFBP-1 Blood Levels in Extremely Preterm Infants: Relationships with Indicators of Placental Insufficiency and with Systemic Inflammation

Alan Leviton, Elizabeth N Allred, Raina N Fichorova, Deborah K VanderVeen, T Michael O’Shea, Karl Kuban, Olaf Dammann, ELGAN Study Investigators

Am J Perinatol. 2019 Jan 27. doi: 10.1055/s-0038-1677472.

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We measured the concentrations of IGF-1 and IGFBP-1, as well as 25 other proteins in blood spots collected weekly from ≥ 880 infants born before 28th week of gestation, and sought correlates of concentrations in the top and bottom quartiles for gestational age and day the specimen was collected. Medically indicated delivery and severe FGR were associated with low concentrations of IGF-1 on first postnatal day and with high IGFBP-1 on almost all days. Elevated IGF-1 and IGFBP-1 were accompanied by elevated concentrations of many other proteins with inflammatory, neurotrophic, or angiogenic properties. Disorders associated with impaired placenta implantation and severe FGR appear to account for a relative paucity of IGF-1 on the first postnatal day. Elevated concentrations of IGF-1 and especially IGFBP-1 were associated with same-day elevated concentrations of inflammatory, neurotrophic, and angiogenic proteins.