Alan Leviton, Robert M Joseph, Raina N Fichorova, Elizabeth N Allred, H Gerry Taylor, T Michael O’Shea, Olaf Dammann
J Neuroimmune Pharmacol. 2018 Sep 6. doi: 10.1007/s11481-018-9804-7.
We evaluated the relationship between inflammatory proteins (IP) and neurotrophic proteins (NP) during first postnatal month in 692 ELGAN children and executive function (EF) limitations among 10-year olds who had IQ ≥ 70. Increased risks of executive dysfunction associated with high concentrations of IP (IL-8, TNF-α, and ICAM-1) were modulated by high values of NP. Modulation by NP of increased risk associated with IP was seen for the working memory limitation, but only with high IL-8 and TNF-α, and switching limitation was only seen with high ICAM-1.values. Risks of EF limitations might be explained by perinatal systemic inflammation in absence of adequate neurotrophic capability.