Inflammation-initiating illnesses, inflamm-related proteins, and cognitive impairment in extremely preterm infants

T Michael O’Shea, Bhavesh Shah, Elizabeth N Allred, Raina N Fichorova, Karl C K Kuban, Olaf Dammann, Alan Leviton, ELGAN Study Investigators

Brain Behav Immun. 2013 ;29:104-12

PubMed Link

The combo of NEC & vent on day 14, and of bacteremia & vent on day 14 elevated risk of MDI <55. Persistently or recurrently elevated concentration of each of the following proteins provided additional information about an increased risk of MDI <55: CRP, SAA, IL-6, TNF-alpha, IL-8, MIP-1beta, ICAM-1, E-SEL, and IGFBP-1.