Systemic inflammation associated with mechanical ventilation among extremely preterm infants

Carl L Bose, Matthew M Laughon, Elizabeth N Allred, T Michael O’Shea, Linda J Van Marter, Richard A Ehrenkranz, Raina N Fichorova, Alan Leviton, ELGAN Study Investigators

Cytokine. 2013;61:315-22

PubMed Link

Newborns ventilated for 7-13 days and 14 days (N=330) (v. < 7 days (N=247),  were more likely to have ↑ IL-1β & TNF-α, IL-8, MCP-1ICAM-1, and MMP-9, and less likely to have elevated RANTES & MIP-1β, MMP-1, and VEGF. These relationships were not confounded by chorioamnionitis, antenatal corticosteroid exposure, or bacteremia.