Maternal obesity and development of the preterm newborn at 2 years

Jelske W van der Burg, Elizabeth N Allred, Karl Kuban, T Michael O’Shea, Olaf Dammann, Alan Leviton

Acta Paediatr. 2015 Sep;104(9):900-3.

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Compared to mothers with nl BMIs, newborns of obese mothers, but not overweight mothers, were more likely to have Bayley Scales indices > – 3Z-score (mental: OR = 2.1; 95% CI: 1.3, 3.5) (motor: OR = 1.7; 95% CI: 1.1, 2.7). These associations were more prominent in children without intermittent- sustained systemic inflammation (mental: OR = 4.6; 95% CI: 1.6, 14) (motor: OR = 3.7; 95% CI: 1.5, 8.9).Some of impaired development cannot be attributed to confounding due to immaturity, socio-economic correlates, or neonatal systemic inflammation.