The breadth and type of systemic inflammation and the risk of adverse neurological outcomes in extremely low gestation newborns

Karl C K Kuban, T Michael O’Shea, Elizabeth N Allred, Raina N Fichorova, Tim Heeren, Nigel Paneth, Deborah Hirtz, Olaf Dammann, Alan Leviton, ELGAN Study Investigators

Pediatr Neurol 2015;52(1):42-8.

PubMed Link

We evaluated associations between number and type of proteins elevated on two occasions a week apart and diagnoses of VMeg, MC, MDI < 55, CP, MCHAT+, and sxs of ADHD on CBCL Increasing breadth of early neonatal inflammation, indexed by number of protein elevations or number of protein functional classes elevated, is associated with ↑ risk of d/o of brain structure and function in ELGANS. The risk for most outcomes did not rise until at least four proteins in at least two functional categories were ↑. When focused on 10 proteins previously found associated w/ neurological outcomes, we found risk of low MDI on Bayley Scales, MC, and CBCL-defined ADHD ↑ w/higher numbers of recurrently and/or persistently elevated proteins.