Perturbation of gene expression of the chromatin remodeling pathway in premature newborns at risk for BPD

Jennifer Cohen, Linda J Van Marter, Yao Sun, Elizabeth Allred, Alan Leviton, Isaac S Kohane

Genome Biol 2007;8:R210

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To evaluate expression profiling in umbilical cord tissue to discover molecular signatures for staging and determine risk for BPD, we conducted cross-sectional study of ELGANs (n = 54). Sections of umb cord obtained at birth f/ 20 infants w/BPD & 34 peers who did not. Infants who developed BPD had distinct signatures involving chromatin remodeling and histone acetylation pathways, implicated in adult lung ds.