Placenta microbiology and histology and the risk for severe retinopathy of prematurity

Minghua L Chen, Elizabeth N Allred, Jonathan L Hecht, Andrew Onderdonk, Deborah VanderVeen, David K Wallace, Alan Leviton, Olaf Dammann, ELGAN Study

Invest Ophthalmol Vis Sci. 2011 1;52:7052-8

PubMed Link

The co-occurrence of bacteria and inflammation was associated with an increased risk for ROP in zone I (OR, 3.1; 95% CI, 1.02-9.5). Among 339 infants with any placental bacteria, the co-occurrence of (1) inflammation and a GA of 23 – 24 weeks and (2) inflammation and hyperoxia were associated with increased risk for all severe ROP.