Predictive Validity of the Modified Checklist for Autism in Toddlers (M-CHAT) Born Very Preterm

So Hyun Kim, Robert M Joseph, Jean A Frazier, Thomas M O’Shea, Katarzyna Chawarska, Elizabeth N Allred, Alan Leviton, Karl K Kuban, Extremely Low Gestational Age Newborn (ELGAN) Study Investigators

J Pediatr. 2016 Nov;178:101-107

PubMed Link

Using standard criteria, M-CHAT had a sensitivity of 52%, a specificity of 84%, a PPV of 20%, and an NPV of 96%. False-positive and false-negative rates were high among children with hearing and vision impairments. High false-positive rates also associated with lower SES, motor and cognitive impairments, and emotional/behavioral dysregulation at age 2 years. Among extremely preterm children with ASD, almost one-half were not correctly screened by the M-CHAT at age 2 years.