Systemic endogenous erythropoietin and associated disorders in extremely preterm newborns

Mari Holm, Jon Skranes, Olaf Dammann, Raina N Fichorova, Elizabeth N Allred, Alan Leviton

Arch Dis Child Fetal Neonatal Ed. 2016 Sep;101(5):F458-63

PubMed Link

N=867. Day-1 EPO in highest quartile was associated with increased risk for early and persistent resp dysfunction in first 2 wks of life and NEC requiring surgery. Lowest day 1 EPO quartile was associated with decreased risk of mod BPD. Low EPO associated with decreased resp complication risk persisted on day 7. On day 14, highest EPO quartile associated with increased risk of ROP, and BPD not requiring ventilation.