The antecedents and correlates of necrotizing enterocolitis and spontaneous intestinal perforation among infants born before the 28th week of gestation

R Singh, B Shah, E N Allred, M Grzybowski, C R Martin, A Leviton, ELGAN Study co-investigators

J Neonatal Perinatal Med. 2016 May 19;9(2):159-70

PubMed Link

Of 1320 infants, 5% had “medical” necrotizing enterocolitis (mNEC), 6% had “surgical” NEC (sNEC) and 4% had spontaneous intestinal perforation (SIP). Antecedents of mNEC included mother’s identification as Black, consumption of aspirin during the pregnancy, and vaginal bleeding after 12th week of gestation. For sNEC the antecedents were maternal self- support, obesity and anemia during the pregnancy, birth before the 24th week, birth weight ≤750gm, and receipt of fresh frozen plasma (FFP) during first postnatal week. Increased risk of SIP associated with increased placental syncytial knots, birth before 24th week, and FFP receipt during first week.