Systemic Inflammation during the First Postnatal Month and the Risk of Attention Deficit Hyperactivity Disorder Characteristics among 10 year-old Children Born Extremely Preterm

Elizabeth N Allred, Olaf Dammann, Raina N Fichorova, Stephen R Hooper, Scott J Hunter, Robert M Joseph, Karl Kuban, Alan Leviton, Thomas Michael O’Shea, Megan N Scott, ELGAN Study ADHD symptoms writing group for the ELGAN Study Investigators

J Neuroimmune Pharmacol. 2017 Sep;12:531-543.

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Abstract 151 children with ADHD behaviors were identified by parent report, while 128 children were identified by teacher report. Top-quartile concentrations of IL-6R, TNF-α, IL-8, VEGF, VEFG-R1, and VEGF-R2 on multiple days were associated with increased risk of ADHD symptoms as assessed by a teacher. Some of this increased risk was modulated by top-quartile concentrations of IL-6R, RANTES, EPO, NT-4, BDNF, bFGF, IGF-1, PIGF, Ang-1, and Ang-2.