Newborn blood gas derangements of children born extremely preterm and neurocognitive dysfunctions at age 10 years

Alan Leviton, Elizabeth N Allred, Robert M Joseph, T Michael O’Shea, Karl C K Kuban, ELGAN Study Investigators

Respir Physiol Neurobiol. 2017 Aug;242:66-72

PubMed Link

Abstract Among 740 children born extremely preterm, children who had hypoxemia, hyperoxemia, hypocapnia, hypercapnia, and acidemia, sometimes on only one day, and sometimes on two or more days, were more likely than others to have a high illness severity score (within the first 12 postnatal hours), and 10 years later to have multiple dysfunctions compatible with possibility that blood gas derangements are indicators of physiologic instability/vulnerability/immaturity.