The relationship between TSH and systemic inflammation in extremely preterm newborns

Carmen L Soto-Rivera, Raina N Fichorova, Elizabeth N Allred, Linda J Van Marter, Bhavesh Shah, Camilia R Martin, Michael S D Agus, Alan Leviton

Endocrine. 2015 Mar;48(2):595-602

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Elevated TSH in ill ELGANs attributed to THOP. We evaluated whether high TSH in first 2 weeks follow recovery from inflammation, similar to non-thyroidal illness synd. We evaluated relationships between hyperthyrotropinemia (HTT), TSH in highest quartile, and elevated inflammation-related proteins. Elevated inflammation-related proteins in 1st 2 weeks did not precede day-14 HTT. Inflammation on day 7 associated with day-14 HTT if inflammation persisted for 2 weeks. Hypothesis that HTT follows recovery from severe illness (preceding systemic inflammation), is weakly supported. Findings support hypothesis that TSH conveys info about concomitant inflammation.