Endogenous erythropoietin varies significantly with inflammation-related proteins in extremely premature newborns

J Wells Logan, Elizabeth N Allred, Raina N Fichorova, Stephen Engelke, Olaf Dammann, Alan Leviton, ELGAN Study Investigators

Cytokine. 2014 Sep;69(1):22-8.

PubMed Link

We evaluate relationships between endogenous Epo and 25 inflammation-related proteins in ELGANs. The proportion of children with inflammation-associated protein concentrations in top quartile increased with increasing quartile of Epo concentrations on 2 of 3days assessed. The ORs for Epo being in top quartile were significantly elevated among those with an inflammation-related protein concentration in the top quartile. Suggests elevation of Epo is not an epiphenomenon, but instead might promote or reduce inflammation, or promote anti-injury or repair capability.