Two-hit model of brain damage in very preterm newborn: fetal growth restriction & postnatal systemic inflammation

Alan Leviton, Raina N Fichorova, T Michael O’Shea, Karl Kuban, Nigel Paneth, Olaf Dammann, Elizabeth N Allred, ELGAN Study Investigators

Pediatr Res. 2013 73:362-70.

PubMed Link

SGA newborns who did not have systemic were at a greater risk of an MDI <55 than those with neither SGA nor systemic inflammation. SGA infants with elevated (IL)-1β, TNF-α, or IL-8 in first 2 weeks were at even higher risk of an MDI <55 than SGA peers without systemic inflammation and non-SGA peers with systemic inflammation.