Antecedents and correlates of blood concentrations of neurotrophic growth factors in very preterm newborns

Alan Levito, Elizabeth N Allred, Hidemi Yamamoto, Raina N Fichorova, Karl Kuban, T Michael O’Shea, Olaf Dammann, ELGAN Study Investigators

Cytokine. 2017 Jun;94:21-28

PubMed Link

AIM:To identify antecedents and early correlates of low concentrations of neurotrophic growth factors in blood of extremely preterm newborns during the first postnatal month. RESULTS / CONCLUSIONS: The concentrations of 2 neurotrophic proteins, NT4 and BDNF, were low among children delivered for medical (maternal, fetal) indications, and among those who were growth restricted. Children who had top quartile concentrations of NT4, BDNF, and bFGF tended to have elevated concentrations of inflammation-related proteins that day. This pattern persisted for much of the first postnatal month.