Alan Leviton, Elizabeth Allred, Karl C K Kuban, Olaf Dammann, T Michael O’Shea, Deborah Hirtz, Michael D Schreiber, Nigel Paneth, ELGAN Study Investigators
Am J Epidemiol. 2010;172:907-16
Hypoxemia, hyperoxemia, hypocapnia, hypercapnia, and acidosis were associated with multiple indicators of brain damage. The associations were seen with 1 or with 2 or more days’ exposure. Findings suggest individual blood gas derangements do not increase brain damage risk. Rather, the multiple derangements associated with indicators of brain damage might represent immaturity/vulnerability and illness severity.