Blood protein profiles of infants born before 28 weeks differ by pregnancy complication

Thomas F McElrath, Raina Nakova Fichorova, Elizabeth N Allred, Jonathan L Hecht, Mahmoud A Ismail, Huaiping Yuan, Alan Leviton, ELGAN Study Investigators

Am J Obstet Gynecol. 2011;204:418.e1-418.e12

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Cytokines (IL-1β, IL-6, TNFα), cytokine receptors (IL-6R, TNF-R1, TNF-R2), systemic inflammatory proteins (CRP, SAA, MPO), chemokines (IL-8, MCP-1, MCP-4, MIP-1β, RANTES, I-TAC), adhesion molecules (ICAM-1, ICAM-3, VCAM-1, E-selectin), and metalloproteinases (MMP-1, MMP-9) were ↑ after preterm labor, membrane rupture, abruption, and cervical insufficiency. Such pattern not seen after PE or fetal indication-growth restriction. Inflammatory profiles were also associated with maternal vaginitis.