Early postnatal blood concentrations of inflammation-related proteins & microcephaly at two years in infants born before the 28th post-menstrual week

Alan Leviton, Karl C K Kuban, Elizabeth N Allred, Raina N Fichorova, T Michael O’Shea, Nigel Paneth, ELGAN Study Investigators

Early Hum Dev. 2011;87:325-30

PubMed Link

↑ SAA on day 1 and ↑of  five proteins on day 14, (IL-6, TNF-R2, IL-8, MCP-1, and ICAM-1) increased risk of microcephaly. The ten proteins ↑ on two separate days a week apart predicted microcephaly, but not when elevated on only one day, were CRP, SAA, IL-1β, IL-6, TNF-α, IL-8, MCP-1, ICAM-1, E-SEL, IGFBP-1.