Characterization of chorioamnionitis in second trimester C-section placentas and correlation with microorganism recovery from subamniotic tissues

Jonathan L Hecht, Andrew Onderdonk, Mary Delaney, Elizabeth N Allred, Harvey J Kliman, Eduardo Zambrano, Solveig M Pflueger, Chad A Livasy, Ina Bhan, Alan Leviton, ELGAN Study Investigators

Pediatr Dev Pathol 2008;11:15-22

PubMed Link

Subamniotic parenchyma of 835 placentas delivered by c/s cultured and evaluated in blinded fashion. Microbes recovered from 41% of placentas. Microbes found more frequently in placentas with high-grade chorionic plate inflammation: Actinomyces, Prevotella bivia, Corynebacterium sp., Escherichia coli, Peptostreptococcus magnus, multiple species of Streptococci, and Mycoplasma sp., including Ureaplasma urealyticum. These microorganisms were also associated with fetal vasculitis.