Elevated Endogenous Erythropoietin Concentrations Are Associated with Increased Risk of Brain Damage in Extremely Preterm Neonates

Steven J Korzeniewski, Elizabeth Allred, J Wells Logan, Raina N Fichorova, Stephen Engelke, Karl C K Kuban, T Michael O’Shea, Nigel Paneth, Mari Holm, Olaf Dammann, Alan Leviton, ELGAN study investigators

PLoS One. 2015 Mar 20;10(3):e0115083

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We sought to determine whether elevated perinatal (EPO) is associated with risks ofbrain damage, and whether this risk differs by co-occurrence of (ISSI).

Newborns with hyperEPO, regardless of ISSI, were more than twice as likely as those without to have very low (< 55) MDI (OR 2.3; 95% CI 1.5-3.5) and/or PDI (OR 2.4; 95% CI 1.6-3.7) Development Indices, and MC at 2 yrs (OR 2.4; 95%CI 1.5-3.8). Newborns with both hyperEPO and ISSI had significantly increased risks of VMeg, CP-HP MC, and MDI & PDI < 55 (ORs ranged from 2.2-6.3), but not WM lesions or other CP forms.