Systemic Inflammation and Cerebral Palsy Risk in Extremely Preterm Infants

Karl C K Kuban, T Michael O’Shea, Elizabeth N Allred, Nigel Paneth, Deborah Hirtz, Raina N Fichorova, Alan Leviton, ELGAN Study Investigators

J Child Neurol. 2014 Dec;29(12):1692-8

PubMed Link

Protein elevations within 3 ds of birth not associated with CP. Elevations of TNF-α, TNF-α-R1, IL-8, and ICAM-1 on at least 2 days were associated with DP. Recurrent-persistent elevations of IL-6, E-selectin, or insulin-like GFBP-1 were associated with HP. DP and HP were more likely with at least 4 of 9 protein elevations previously associated with MDI<55 & and MC. Repeated elevated proteins during first 2 postnatal weeks are associated w/increased CP risk.