Systemic Inflammation in the Extremely Low Gestational Age Newborn Following Maternal Genitourinary Infections

Raina N Fichorova, Noah Beatty, Rita R S Sassi, Hidemi S Yamamoto, Elizabeth N Allred, Alan Leviton, ELGAN Investigators

Am J Repro Immunol 2015;73(2):162-74

PubMed Link

Compared to their peers whose mother had no UTI or CVI, infants whose mother reported a CVI were more likely on day 1 to have a concentration in the top quartile of CRP, SAA, MPO, IL-1β, IL-6, IL-6R, TNF-α, RANTES, ICAM-3, E-selectin and VEGF-R2. Infants whose mother reported UTI were more likely on d 7 to have concentration in the top quartile of MPO, IL-6R, TNF-R1, TNF-R2, and RANTES. Associations were no longer significant 14 days after birth. GU infections in pregnancy appear to increase the very preterm newborn’s risk of systemic inflammation