Gene Targets for IVH Study Group. Candidate Gene Analysis: Severe Intraventricular Hemorrhage in Inborn Preterm Neonates

Ulrika Adén, Aiping Lin, Waldemar Carlo, Alan Leviton, Jeffrey C Murray, Mikko Hallman, Richard P Lifton, Heping Zhang, Laura R Ment, Gene Targets for Intraventricular Hemorrhage Study Group

J Pediatr 2013;163(5):1503-6.e1

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IVH is a disorder of complex etiology. We analyzed genotypes for 7 genes from 224 inborn preterm neonates treated with antenatal steroids and grade 3-4 IVH and 389 matched controls. Only methylenetetrahydrofolate reductase was more prevalent in cases of IVH, emphasizing the need for more comprehensive genetic strategies.