Systemic inflammation, intraventricular hemorrhage, and white matter injury

Alan Leviton, Elizabeth N Allred, Olaf Dammann, Stephen Engelke, Raina N Fichorova, Deborah Hirtz, Karl C K Kuban, Laura R Ment, T Michael O’shea, Nigel Paneth, Bhavesh Shah, Michael D Schreiber, ELGAN Study Investigators

J Child Neurol. 2013;28:1637-45

PubMed Link

Infants with both IVH and WMI were more likely to have ↑ concentrations of CRP and IL-8 on days 1, 7, and 14, and ↑ SAA and TNF-α on 2 of these days. IVH should be viewed as 2 entities: with-w/o WMI. Each is associated with inflammation, but the combination has a stronger inflammatory signal than hemorrhage alone.