Maternal antenatal complications and the risk of neonatal cerebral WMD and later CP in ELGANs

Thomas F McElrath, Elizabeth N Allred, Kim A Boggess, Karl Kuban, T Michael O’Shea, Nigel Paneth, Alan Leviton, ELGAN Study Investigators

Am J Epidemiol. 2009;170:819-28

PubMed Link

Mothers that received antenatal steroids tended to have lower risks of VM and EL (10% vs. 23%, P < 0.001 and 7% vs. 11%, P = 0.06). Risk of VM was ↑ for infants delivered because of PL (OR = 2.3, 95% CI: 1.1, 4.9), PPROM (OR = 3.6, 95% CI: 1.5, 8.7), and cervical insufficiency (OR = 2.8, 95% CI: 1.4, 5.5) compared to infants delivered because of PE. Risk of an EL was ↑ for infants with PL (OR = 2.7, 95% CI: 1.2, 5.7) and IUGR (OR = 3.3, 95% CI: 1.2, 9.4).

ELGAN