Systemic inflammation associated with severe intestinal injury in extremely low gestational age newborns

Camilia R Martin, Melissa Bellomy, Elizabeth N Allred, Raina N Fichorova, Alan Leviton

Fetal Pediatr Pathol. 2013 ;32:222-34

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On days 7 & 14, infants with NEC had ↑ levels of CRP, SAA, IL-6 and IL-8. Infants with intestinal perf had ↑ levels of CRP and IGF binding protein-1 on day 7 and elevated CRP, SAA, TNF-receptor-2 and MMP-9 on day 14.