Systemic responses of preterm newborns with presumed or documented bacteraemia

Alan Leviton, T Michael O’Shea, Francis J Bednarek, Elizabeth N Allred, Raina N Fichorova, Olaf Dammann, ELGAN Study Investigators

Acta Paediatr. 2012;101:355-9

PubMed Link

Newborns with presumed early (week 1) bacteraemia had ↑ concentrations of only a few inflammation-related proteins, while those who had presumed late (weeks 2-4) bacteraemia did not have any elevations. In contrast, newborns who had documented early bacteraemia or late bacteraemia had a strong inflammatory signal with more protein concentrations elevated on two separate occasions a week apart.