The relationship between early concentrations of 25 blood proteins and cerebral white matter injury in preterm newborns: the ELGAN study

Alan Leviton, Karl Kuban, T Michael O’Shea, Nigel Paneth, Raina Fichorova, Elizabeth N Allred, Olaf Dammann

J Pediatr. 2011;158:897-903.e1-5

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VEGF receptor 1, SAA, and MIP 1β on day 1 and IL-8 on day 7 were associated with increased risk of VM. Elevated MIP 1β on day 1 and ICAM-1 on day 7 were associated with risk of EL lesion. Elevated inflammation-related proteins on two separate days were at significantly ↑ risk for VM, & modestly ↑ risk for EL.

ELGAN